Fri Feb 07 2025

149 articles - From Friday Jan 31 2025 to Friday Feb 07 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gastroenterology

A Standardized Approach to Performing and Interpreting FLIP Panometry for Esophageal Motility Disorders: The Dallas Consensus.

The standardized approach for performance and interpretation of the Dallas Consensus can facilitate use of FLIP Panometry in broad clinical settings.

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Gastrointest Endosc

American Society for Gastrointestinal Endoscopy position statement on periendoscopic management of patients on glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors.

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Meta-analysis

meta-analyses and systematic reviews

Hepatology

Comparison of pharmacological therapies in metabolic dysfunction-associated steatohepatitis for fibrosis regression and MASH resolution: Systematic review and network meta-analysis.

This study provides updated rank-order efficacy of MASH pharmacological therapies for fibrosis regression and MASH resolution. These data are helpful to inform practice and clinical trial design.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Chronic Use of Proton Pump Inhibitors Is Associated With Reduced 30-Day Mortality From Acute Pancreatitis.

Compared to non-users, patients on chronic PPIs were older (p < 0.001) and had a higher Charlson Comorbidity Index score (p < 0.001). Mortality rates at 30 days were 1.5% in chronic PPI users and 4.6% in non-users (OR 0.33; 95% CI, 0.16-0.6; p < 0.001).

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Crohn's Disease With Latent Tuberculosis Infection or Intestinal Tuberculosis: Rapid Discrimination by Targeted Next-Generation Sequencing.

TNGS using fresh biopsy tissue from ulcer bases is highly sensitive and specific, with superiority over other traditional diagnostic methods for ITB detection. TNGS could facilitate rapid diagnosis of ITB and discrimination from CD with LTBI, particularly in high TB-endemic countries.

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Impact of GLP-1 Receptor Agonists on Alcohol-Related Liver Disease Development and Progression in Alcohol Use Disorder.

GLP-1RAs were associated with reduced risks of developing and progressing ArLD in patients with AUD, suggesting potential therapeutic benefits in this population.

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Am J Gastroenterol

Fecal Calprotectin Correlates with Disease Extent but Remains a Reliable Marker of Mucosal Healing in Ulcerative Colitis.

FC showed a significant association with disease extent yet remained a reliable surrogate marker for mucosal healing across al disease extents.

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HIV Infection Is Associated With a Less Aggressive Phenotype of Inflammatory Bowel Disease: A Multicenter Study of the ENEIDA Registry.

In the multivariate analysis, HIV infection (odds ratio 4.765, 95% confidence interval (CI) 2.48-9.14; P < 0.001) and having ≥1 comorbidity (OR 2.445, 95% CI 1.23-4.85; P = 0.010) were risk factors for developing OI, while CD was protective (OR 0.372, 95% CI 0.18-0.78; P = 0.009). HIV infection seems to be associated with a less aggressive phenotype of IBD and a lesser use of nonbiological therapies and biologicals but entails a greater risk of developing OI.

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Inequalities in developing cirrhosis complications over time: A cohort study.

In a contemporary cirrhosis cohort, half of patients progressed, while others remain compensated, and a large fraction transitioned directly to death, with age and etiology significantly influencing outcomes. These data highlight the importance of interventions in the high-yield period before the first complication.

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Large Single Center Comparison Of Novel and Reusable Duodenoscopes Show Similar Contamination Rates That Do Not Correlate With Clinical Infection.

Our data suggest bacterial contamination rates of novel duodenoscopes with disposable caps and reusable duodenoscopes are similar. The low contamination rates in this study support consistent high-level disinfection practices regardless of duodenoscope generation.

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PROBIOTICS PRESCRIBED WITH HELICOBACTER PYLORI ERADICATION THERAPY IN EUROPE: USAGE PATTERN, EFFECTIVENESS, AND SAFETY: Results from the European Registry on Helicobacter pylori Management (Hp-EuReg).

In Europe, the use of probiotics was associated with higher effectiveness and safety of H. pylori eradication therapy. Lactobacillus improved treatment effectiveness, while Bifidobacterium and Saccharomyces were associated with a better safety profile.

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Predictors for chronic opioid use in patients with inflammatory bowel disease - a population based cohort study.

An alarming proportion of patients became chronic opioid users. These results are helpful to risk-stratify patients to prevent chronic opioid use. Clinicians should be particularly attentive in patients who have had surgery, who use hypnotics/sedatives, and who are elderly. We need evidence regarding pain management strategies, efficacy of non-opioid analgesics, and opioid cessation strategies.

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Severe Cholestasis Predicts Recurrent Primary Sclerosing Cholangitis Following Liver Transplantation.

Severe cholestasis at 3 months in the Canadian cohort was predictive of graft loss (HR = 3.88, P = 0.0001). The development of cholestasis within 3-12 months following LT was predictive of rPSC and graft loss.

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Clin Gastroenterol Hepatol

Association of Alcohol and Incremental Cardiometabolic Risk Factors with Liver Disease: A National Cross-Sectional Study.

Stratifying MetALD as ≥3 CMRFs, rather than 1 CMRF may provide more optimal fibrosis stratification. Diabetes, high waist circumference, and hypertension, are associated with significant liver fibrosis among individuals with increased alcohol use, but not dyslipidemia.

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Colorectal cancer incidence in steatotic liver disease (MASLD, MetALD, and ALD).

The risk of CRC differs significantly among patients with SLD, with the highest incidence observed in those with ALD, followed by MetALD and MASLD.

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Diagnosis of Retrograde Cricopharyngeus dysfunction using high resolution impedance manometry and comparison with control subjects.

Rapid drinking challenge with sparkling water can serve as belch provocation test during HRiM, with higher UES pressures during gas reflux and oscillations discriminating R-CPD patients from controls.

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Endoscopic Ultrasound Guided Portosystemic Pressure Gradient Correlates with Clinical Parameters and Liver Histology.

Results Across 8 centers, 385 patients were enrolled and 373 had successful EUS-PPG (technical success 97%). Higher median PPGs were observed in patients with than without esophageal varices (11.6mmHg vs 4.1), portal hypertensive gastropathy (10.5mmHg vs 3.3), and thrombocytopenia (7.6 mmHg vs 4.4) (p 5mm Hg which outperformed non-invasive markers of fibrosis.

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Extended Risankizumab Treatment in Patients With Crohn's Disease Who Did Not Achieve Clinical Response to Induction Treatment.

Most initial nonresponders to IV RZB induction who received 12W of extended RZB treatment demonstrated improved clinical and endoscopic outcomes at W24. Improvements in patients who received SC RZB extended treatment were maintained during FORTIFY. Extended treatment was well tolerated with no new safety risks identified.

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The assessment of gastrointestinal transit by the Atmo Capsule: A comparison with the SmartPill Capsule.

The performance characteristics of the Atmo capsule for measurements of GET and CTT, were equivalent to the reference standard WMC with a strong correlation and good device agreement. These results demonstrate that the Atmo Capsule is a valid method for evaluating gastrointestinal transit.

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Endoscopy

Artificial intelligence improves submucosal vessel detection during third space endoscopy.

AI improved the vessel detection rate and time of endoscopists during third space endoscopy. While these data need to be corroborated by clinical trials, AI may prove to be an invaluable tool for the improvement of endoscopic interventions.

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Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative - Update 2025.

Since 2019, there has been an increase in published studies looking at different aspects of small-bowel endoscopy, including real-world data. This paper provides an update on the 2019 performance measures, considering the latest literature.

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Standard enhancement settings used on endoscopy systems significantly impair performance of artificial intelligence systems in endoscopy.

This retrospective study indicates that performance of current endoscopic AI systems can substantially vary depending on the post-processing enhancement settings of the endoscopy unit. Specific data augmentation can mitigate this performance loss.

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Gastroenterology

A novel, IBS-specific IgG ELISA-based elimination diet in irritable bowel syndrome: A randomized, sham-controlled trial.

Subjects on an IgG-guided elimination diet were more likely to achieve the primary endpoint than those on a sham elimination diet. Subgroup analysis suggests a more robust benefit for subjects with IBS-C and IBS-M. This highlights the potential effectiveness of a personalized elimination diet based on a novel IBS-specific IgG assay. A larger study is warranted to validate these observations.

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Overlap of Genomic and Transcriptomic Genes Identified in Familial Eosinophilic Esophagitis.

Genes related to immune response, barrier dysfunction, and cell adhesion were identified in familial EoE cases and unaffected family members, supporting a genetic familial predisposition and a possible multi-hit background to disease pathophysiology.

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Gastrointest Endosc

Endoscopist adenoma detection rate associated with neoplasia detection during subsequent-round colonoscopy in fecal immunochemical test-based colorectal cancer screening: cross-sectional analysis of the SCREESCO randomized controlled trial.

The multivariable odds ratios of the first-round intermediate and high ADRs, compared with the very low ADR, for the second-round ACN detection, were 0.17 (95% confidence interval: 0.02-0.79) and 0.19 (95% confidence interval: 0.04-0.86), respectively. The impact of endoscopists' ADRs on ACN detection in subsequent-round colonoscopies underscores the importance of considering ADR for optimal follow-up after first-round colonoscopy in a FIT-based screening program.

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SURVEILLANCE FINDINGS IN HIGH-RISK PATIENTS AFTER BASELINE COMPUTER-ASSISTED DETECTION COLONOSCOPY: A PROPENSITY SCORE MATCHING ANALYSIS.

The cumulative incidence of patients with any metachronous adenoma or serrated lesion was significantly lower in patients with baseline use of CADe than conventional colonoscopy (log rank p=0.05). Patients who had CADe use at baseline colonoscopy had significantly lower rates of metachronous lesions, including advanced adenoma, on surveillance colonoscopy.

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Thirty-day hospital admission following high-risk outpatient ERCP: incidence and analysis of risk factors based on a secondary analysis of the Stent Versus Indomethacin trial dataset.

High-risk patients who undergo outpatient ERCP and are discharged home are at considerable risk for hospital admission within 30 days and have increased rate of pancreatitis and longer length of hospital stay compared to outpatients admitted to the hospital immediately following ERCP, and some factors may predict this outcome. These findings should influence decision making and informed consent when electing to proceed with high-risk ERCP, recognizing that patients with sphincter of Oddi dysfunction were over-represented in this cohort, which may limit generalizability to a typical ERCP practice.

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Gut

Carbon footprinting and environmental impact of gastrointestinal endoscopy procedures at a tertiary care institution: a prospective multi-dimensional assessment.

This study highlights the significant environmental footprint of GIE procedures, emphasising the importance of optimising practices to reduce patient travel and repeat procedures, alongside improving electricity and water management for sustainable healthcare.

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Dysbiotic oral microbiota-derived kynurenine, induced by chronic restraint stress, promotes head and neck squamous cell carcinoma by enhancing CD8<sup>+</sup> T cell exhaustion.

CRS-induced oral microbiota dysbiosis plays a protumourigenic role in HNSCC and can influence host metabolism. Mechanistically, under stress conditions, Kyn promotes CD8 + T cell exhaustion and HNSCC tumourigenesis through stabilising AhR by its deubiquitination.

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Glucocorticoid receptor suppresses GATA6-mediated RNA polymerase II pause release to modulate classical subtype identity in pancreatic cancer.

Conversely, in basal PDAC ΔNp63 promotes Pol II recruitment and stabilises enhancer-promoter interactions. This study provides new insights into the transcriptional control and role of GR agonists in controlling PDAC molecular subtype identity.

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Hepatology

Coil or Plug-Assisted Retrograde transvenous obliteration (CARTO/PARTO) for treating portal hypertensive variceal bleeding: A multi-center, real-world 10-year retrospective study.

CARTO and PARTO have excellent long-term survival and clinical outcomes. However, these are negatively affected by high MELD scores, concomitant HCC, and coexisting esophageal varices.

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Multicenter, retrospective GUIDANCE001 study comparing transarterial chemoembolization with or without tyrosine kinase and immune checkpoint inhibitors as conversion therapy to treat unresectable hepatocellular carcinoma: Survival benefit in intermediate or advanced, but not early, stages.

However, it was also associated with a significantly higher frequency of serious adverse events (35.6 vs 27.0%, p=0.009). Combining TACE with immune checkpoint and tyrosine kinase inhibitors was associated with significantly better survival and conversion efficacy than TACE alone among patients with intermediate or advanced unresectable HCC.

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Phosphoproteomics delineates hepatocellular carcinoma subtypes and pinpoints therapeutic targets.

Our study provides a comprehensive exploration of the phosphoproteomic landscape of HCC, establishing new subtypes that match clinical features and identifying potential therapeutic targets for the most malignant C subtype.

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J Hepatol

Accumulation of altered serum bile acids predicts liver injury after portoenterostomy in biliary atresia.

Accumulation and altered composition of serum bile acids predicted progressive liver disease and poorer transplant-free survival following KPE. Poor prognosis was associated with low bile acid synthesis and aberrantly increased liver FGF19. Impact and implications Biliary atresia (BA), a fibro-obliterating biliary disease of infants, remains the most common indication for pediatric liver transplantation caused by rapid progression of liver injury. To identify predictive biomarkers of disease progression and to elucidate the pathophysiology of BA liver injury, we profiled serum bile acids and studied their liver metabolism after Kasai portoenterostomy. Accumulation and altered composition of circulating bile acids predicted progression of liver disease and need for liver transplantation. Patients with poor prognosis showed low bile acid synthesis and abnormal liver expression of fibroblast growth factor 19.

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Hyodeoxycholic acid ameliorates cholestatic liver fibrosis by facilitating m<sup>6</sup>A-regulated expression of a novel anti-fibrotic target ETV4.

The present study underscores ETV4 as a novel anti-fibrotic target and demonstrates that HDCA remodels ECM by facilitating m 6 A-regulated ETV4 expression, offering potential therapeutic approaches for cholestatic liver fibrosis. Impact and implications This study delves into the underlying mechanisms of cholestatic liver fibrosis and offers potential therapeutic targets. The research highlights ETV4 as a novel anti-fibrotic target and is essential for the therapeutic effects of hyodeoxycholic acid (HDCA) against cholestatic liver fibrosis. These findings are important for both the scientific community and patients with cholestatic liver diseases, offering valuable insights for future therapeutic strategies that focus on regulating m 6 A-dependent epigenetic modifications of anti-fibrotic targets like ETV4 and developing new interventions utilizing HDCA.

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Loss of SGK1 supports metastatic colonization in hepatocellular carcinoma by promoting resistance to T cell-mediated immunity.

These findings establish SGK1 as a crucial regulator of immune-mediated control over metastatic growth in HCC. SGK1 expression in metastatic lesions may serve as a predictive biomarker for response to immune checkpoint inhibitors, presenting new avenues for therapeutic intervention to overcome immune resistance in metastatic HCC. Impact and implications Despite metastasis is a common occurrence and lethal determinant in cancers, the mechanism underlying tumor immune evasion during metastatic seeding is unclear. Our study reveals that loss of Sgk1 renders metastatic tumor cells survival advantages against antitumor immune response by abrogating CD8 + T cell-induced RIPK1-dependent necroptosis. Growth of Sgk1-silenced metastasis led to infiltration of terminally exhausted CD8 + T cells, which could be reversed by immune checkpoint inhibitors administered at early stage of metastatic seeding. These findings provide valuable insights into potential therapeutic strategies targeting resistance to T cell immunity in cancer metastasis.

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Multiomic analysis uncovers a continuous spectrum of differentiation and Wnt-MDK-driven immune evasion in hepatoblastoma.

Our novel findings, revealing a continuous spectrum of tumor differentiation states and Wnt-MDK-driven immune evasion, are significant for pediatric oncology clinicians and researchers, improving our functional understanding of the immune environment of hepatoblastoma. The identification of midkine as a tumor-specific immunomodulator suggests a potential for developing new targeted therapies, though further mechanistic and practical validation would be needed to realize clinical translation of these findings.

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Number of people treated for hepatitis C virus infection in 2014-2023 and applicable lessons for new HBV and HDV therapies.

In the last 10 years, 21% of al HCV infections were treated with DAAs. Regional and temporal variations highlight the importance of active screening strategies. Without program enhancements, the number of treated PLHCV stalled in every country/region which may not reflect a lower prevalence but may instead reflect the diminishing returns of the existing strategies. Impact and implications Long-term hepatitis C virus (HCV) infection can lead to cirrhosis and liver cancer. Since 2014, these infections can be effectively treated with 8-12 weeks of oral therapies. In 2015, the World Health Organization (WHO) established targets to eliminate HCV by 2030, which included treatment targets for member countries. The current study examines HCV treatment patterns across 119 countries and regions from 2014 to 2023 to assess the impact of national programs. This study can assist physicians and policymakers in understanding treatment patterns within similar regions or income groups and in utilizing historical data to refine their strategies in the future.

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The Freiburg Index of Post-TIPS Survival (FIPS) identifies patients at risk for further decompensation and ACLF after TIPS.

These events are responsible for impaired transplant-free survival in FIPS high-risk patients. These results pave the way for the development of tailored clinical management strategies.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial on 'Early HBcrAg and Anti-HBc Levels Identify Patients at High Risk for Severe Flares After Nucleos(t)ide Analogue Cessation: A Pooled Analysis of Two Clinical Trials'.

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Editorial: Alpha<sub>2</sub>-Delta Ligands in Irritable Bowel Syndrome.

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Editorial: Autoimmune Hepatitis-Could It Be as Easy as Vitamin D?

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Editorial: Baseline Drug Clearance Predicts Outcomes in Children With Inflammatory Bowel Disease Treated With Vedolizumab.

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Editorial: Flipping the Script-Higher Risk of Hepatocellular Carcinoma With Tenofovir Compared to Entecavir in a French Population-Based Cohort.

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Review Article: Surrogate Endpoints to Assess Treatment Efficacy in Disorders of Gut-Brain Interaction of Lower Gastrointestinal Tract.

With the exclusion of alosetron data, CT at 24 h was non-significantly correlated with the composite/global symptom endpoint (Rs = -0.667, p = 0.073), but not with abdominal pain (Rs = 0.377, p = 0.419). Scintigraphic CT measurement fulfils the expectation of a surrogate endpoint for symptom-based outcomes, particularly in IBS-D or IBS-C and CIC.

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Clin Gastroenterol Hepatol

Diagnosis and Treatment of Hemochromatosis.

In this review, the emphasis is on recent developments in the diagnosis and treatment of hemochromatosis, focusing on those homozygous for the C282Y variant in the HFE gene. In this condition, there is a clear need for earlier diagnosis leading to earlier treatment to prevent morbidity and mortality from iron overload.

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Melting the Celiac Iceberg to Improve Outcomes in Celiac Disease: Two Tales of Success.

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Gastroenterology

"A rose by any other name"? - Beyond Diagnostic Nomenclature in Neurogastroenterology.

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Gut Microbiome Signature in Predisease Phase of Inflammatory Bowel Disease: Prediction to Pathogenesis to Prevention.

Understanding these changes in the predisease phase provides a means of predicting IBD in high-risk populations and offers insights into possible mechanisms involved in disease pathogenesis. Finally, we discuss strategies to use this information to design interventions aimed at modulating the microbiome as a means of preventing or delaying the onset of IBD.

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Is fecal immunochemical testing the right FIT for patients with symptoms?

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Gastrointest Endosc

A note from the Editor-in-Chief.

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Acetic acid-enhanced magnifying endoscopy with narrow-band imaging: A simple, efficient, and nontoxic alternative chromoendoscopy for pit pattern analysis in colorectal neoplasm?

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Assessment of esophageal injury after thermal ablation for atrial fibrillation: a possible new EUS indication.

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Is this the end game in the treatment of gastric varices?

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Under pressure: changing our way of caring.

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Unsedated colonoscopy: Are we there yet?

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Gut

Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications.

With this review, we aim to provide a comprehensive survey of the studies that have applied single-cell omics to the study of UC or CD, and offer our perspective on the main findings these studies contribute. Finally, we discuss the limitations and potential benefits that the integration of single-cell omics into clinical practice and drug development could offer.

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J Hepatol

Loss or gain of function: The functional complexity of the PNPLA3 I148M Variant.

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MOVING DIAGNOSIS OF LIVER FIBROSIS INTO THE COMMUNITY.

In addition, intervention on metabolic risk factors and alcohol consumption should be carried out in collaboration between specialized therapy and primary care. This review describes liver fibrosis from the community perspective, highlighting gaps in knowledge on how to define the optimal combination of tests, target population, the ideal pathway of care for CLD, and how to increase implementation of programs for early diagnosis of liver diseases in clinical practice.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

A Global Perspective on Metabolically Driven Primary Liver Cancer: Opportunities and Challenges.

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ACG 2024 Presidential Speech.

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Biliary obstruction secondary to Ascaris lumbricoides.

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Cholangioscopy for Primary Sclerosing Cholangitis With Biliary Strictures Using Texture and Color Enhancement Imaging and Red Dichromatic Imaging.

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Effects of Cholestasis on Primary Sclerosing Cholangitis in Patients Following Liver Transplantation: Insights From Mixed Censoring Outcomes.

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Is It Time to Scale Down the Bristol?

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Lyon Score: Key Deficiencies and Discrepancies.

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Response to Kong and Li.

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Response to Melton et al.

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Second Trimester Twist: Sigmoid Volvulus as a Rare Cause of Abdominal Pain During Pregnancy.

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The Management of Gastroparesis Symptoms.

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Unexpected Cause of Abdominal Pain: Rectal Seed Bezoar.

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When Patients With IBD Require an Ostomy: Evidence-Based Answers to 10 Common Clinical Questions in IBD Surgery.

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When a Pancreatic Mass Isn't Malignant: A Case of Pancreatic Splenosis.

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Clin Gastroenterol Hepatol

A machine-learning model score predicts advanced fibrosis and cirrhosis in indeterminate FIB-4 patients.

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Diffuse Esophageal Adenocarcinoma.

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IL-17A inhibitor-induced pouchitis.

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Outcomes in Female Patients with Chronic Liver Disease Undergoing Infertility Treatment.

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Safety and clinical effectiveness of GLP1 receptor agonists in inflammatory bowel disease patients.

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Endoscopy

A new innovative imaging modality: "extended reality" in endoscopic ultrasonography.

Pubmed   Journal   ReadQx   PMC

A stent too far: endoscopic ultrasonography-guided duodenojejunostomy for malignant duodenal obstruction after placement of a stent in the horizontal part.

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Adenoma with complete circumferential involvement of the ileum and ileocecal valve successfully removed by traction-assisted endoscopic submucosal dissection.

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Application of holmium laser in endoscopic retrograde cholangiopancreatographygall gallbladder-preserving cholecystolithotomy.

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Backward leap technique using a novel 0.018-inch guidewire.

Pubmed   Journal   ReadQx   PMC

Be cautious with the semilunar fold! Endoscopic perforation after cap-suction pseudopolyp formation for underwater en bloc resection of a big cecal lesion.

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Cholangioscope-assisted endoscopic retrograde appendicitis therapy for the diagnosis and treatment of occult appendicitis with a giant fecalith.

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Ectopic mediastinal parathyroid diagnosed by contrast-enhanced endoscopic ultrasound-guided fine-needle aspiration and eluate parathormone level.

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Endoscopic resection with one-port placement for duodenal neuroendocrine tumor: toward more minimally invasive endoscopic management.

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Endoscopic transcecal appendectomy for a laterally spreading tumor of the appendiceal stump.

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Facilitating transpancreatic biliary sphincterotomy with a rotatable sphincterotome: a case of improved biliary cannulation.

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Hemostasis of active bleeding in the duodenal bulb using a sharp-clawed reopenable endoclip under gel immersion endoscopy.

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Multi-strategy endoscopic submucosal dissection of a challenging lesion.

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Novel methods to confirm successful puncture in endoscopic ultrasound-guided hepaticogastrostomy.

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Opportunistic myiasis is a rare complication in patients with feeding gastrostomy tube.

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Over-the-scope clip on over-the-scope clip technique for closure of delayed perforation near a previously placed over-the-scope clip.

Pubmed   Journal   ReadQx   PMC

Single-use cholangioscope-assisted diagnosis of a large sessile serrated lesion within the appendix.

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Stent-in-stent deployment for malignant hilar obstruction using multi-hole stent can prevent tumor ingrowth during 6-month cholangioscopic follow-up.

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Submucosal tunneling endoscopic resection of a rare gastric hemangioma.

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Successful balloon fixation technique to prevent dislocation of a fully covered self-expanding metal stent for biliary stricture.

Pubmed   Journal   ReadQx   PMC

Time to focus on the potential benefit of minimally invasive treatment of remnant cystic duct stump stones.

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Gastroenterology

A Microbiome-directed therapy for malnutrition that performs better than standard nutritional interventions.

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A new tool to study the DREADDed peripheral nervous system.

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Acute Liver Failure and a Rash.

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An Unexpected Adverse Event of Radiofrequency Ablation for Intraductal Papillary Mucinous Neoplasm.

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First-line dual immunotherapy to checkmate metastasic colorectal cancer with high microsatellite instability.

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Liver Health: An Emerging Concept.

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Mirikizumab for Crohn's Disease: Small Step Forward or Giant Leap Ahead?

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Names matter: a call to neurogastroenterologists to examine how we can improve the nomenclature we use to describe the disorders our patients experience.

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Prevalence of Chronic Liver Diseases and Associated Risk Factors in Sexual Minority People in The United States.

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Teaching and Assessing Higher-order Cognitive Skills in Fellowship Training.

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The safety and efficacy of guselkumab for the treatment of moderate to severely active ulcerative colitis.

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Gastrointest Endosc

At the Focal Point: ERCP in Altered Anatomy: Managing a Large Bile Duct Stone in a Type 4 Hiatal Hernia using a Savary wire.

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Cholangioscopy-Based Treatment and Diagnosis of an Infrequent Cause of Jaundice: Common Bile Duct Polyp.

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Gut

Histology of subepithelial lesions (SELs) in the gastrointestinal tract-resected endoscopic: a database study of 4901 patients.

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Hepatology

Beyond monotherapy: Combining radiotherapy with sintilimab and bevacizumab for hepatocellular carcinoma with portal vein tumor thrombus.

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FIB-4 and VITRO: A new dynamic duo in noninvasive testing?

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Identifying the sweet spot in portal pressure reduction with TIPS.

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Reply: Interpreting the 100% disease control rate of Sin-Bev-RT in HCC with PVTT.

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Second Line, Still Fine.

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Setting the standard: Quality indicators in variceal hemorrhage.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: A Prospective Study on the Prevalence of MASLD in Patients With Type 2 Diabetes and Hyperferritinaemia.

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Letter: Clinical Trial Design Considerations for Hospitalised Patients With Ulcerative Colitis Flares and Application to Study Hyperbaric Oxygen Therapy in the NIDDK HBOT-UC Consortium.

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Letter: Enhancing the Analysis and Clinical Applicability of Ferritin as a Biomarker for MASLD in Type 2 Diabetes Patient.

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Letter: Hepatotoxicity in Malignancies Under ICIs Treatment.

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Letter: Optimising Prevention of Adverse Events and Antiviral Prophylaxis for HBV-Infected HCC Patients Undergoing Immunotherapy.

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Letter: Refining the Understanding of Hepatic Steatosis and Cardiovascular Risk-Addressing Key Variables and Subgroup Analyses.

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Clin Gastroenterol Hepatol

Guarding the Gate: The Sentinel Role of Endosonography in Precluding Unwarranted.

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Piecemeal Endoscopic Mucosal Resection is Appropriate for the Majority of Large Nonpedunculated Polyps In The Right Colon.

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Gastroenterology

Bridging Fairness Gaps in Artificial Intelligence Risk Prediction for Gastrointestinal Bleeding.

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Comment on "An Empirical Dietary Pattern Associated with the Gut Microbial Features in Relation to Colorectal Cancer Risk".

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Comments on "Recompensation of Chronic Hepatitis C-Related Decompensated Cirrhosis Following Direct-Acting Antiviral Therapy: Prospective Cohort Study From a Hepatitis C Virus Elimination Program".

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Considerations on the Electronic Health Record-Based Machine Learning Model for Gastrointestinal Bleeding.

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Machine Learning in Gastrointestinal Bleeding Risk Stratification: Promising Advances and Remaining Challenges.

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Mitigating bias in colorectal cancer research: assessing the limitations of the Cox proportional hazards model and considering alternative methods.

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Reassessing the Inputs for a Machine Learning Model in Gastrointestinal Bleeding Risk Stratification.

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Regarding "An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk".

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Gastrointest Endosc

Comparative efficacy of short versus standard esophageal myotomy in sigmoid-type achalasia treatment.

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Endoscopic submucosal dissection with adaptive traction strategy.

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Evaluating limitations and long-term outcomes in short versus standard myotomy for achalasia.

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Exploring possible enhancements.

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Standardizing the endoscopic management of pancreatic walled-off necrosis: the crucial role of magnetic resonance imaging.

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Through-the-scope proximal flange fixation: "Edging" toward single-session procedures for all?

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Transoral incisionless fundoplication.

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J Hepatol

Association of Metabolic Signatures of Air Pollution with MASLD: A Note on Data Consistency.

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Beyond Portal Hypertension: Characterizing Porto-Sinusoidal Vascular Disorder in Patients without signs of PH.

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HEPATIC NODULE AND RISING AFP LEVELS: COULD IT INDICATE A BENIGN CONDITION?

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Increased HBsAg loss in HBeAg-negative patients with chronic hepatitis B and concurrent MASLD.

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Metabolic dysfunction-associated steatotic liver disease may increase intrahepatic interferon gene signatures in patients with chronic hepatitis B.

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Response letter 'Plasma exchange does not improve overall survival in patients with acute liver failure in a real world cohort'.

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Response to: Unlock AI-Safe-C score's potential at all levels: Improve methods and overcome barriers.

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